Glycosaminoglycans (GAG)

Posted on 3:05 PM | By fahd almutairi | In

ـLong, unbranched polysaccharide chains (70-200 sugar residues ) composed of repeating disaccharide sugar units। The repeating disaccharides are linked by 1,4 linkages in βconfiguration.

Highly negatively charged due to sulfate and carboxyl groups.Which attract Na+ions and water.

One of two sugar residues in repeating disaccharide is always an amino sugar and may contain uronic acid

N-acetylglucosamine

N-acetylgalactosamine

ـmain groups of GAGs, distinguished by sugar residues, type of linkage between residues and number and location of sulfate groups

Hyaluronicacid

Chondroitin4 sulfate and chondroitin6 sulfate

Dermatansulfate

Heparansulfate and heparin

Keratansulfate I, II

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